Low Dose Naltrexone

Low Dose Naltrexone is a truly intriguing and unique medication that represents a new frontier in the management of a whole array of medical conditions. The citizens of the US are facing an almost exponential rise in the diagnosis of a widespread range of autoimmune diseases, leading to a health care crisis of almost unmanageable levels. There is no clear understanding for this rising occurrence, and no successful approach to effectively address and treat all these conditions.

Compounded Low Dose Naltrexone (LDN)—

The Apothecary compounds Low Dose Naltrexone (LDN) for individuals of all ages to alleviate a broad range of symptoms—from the effects of inflammation, chronic pain, mental health, autoimmune diseases, dermatology, and gastrointestinal issues. The beneficial broad range of effects that LDN creates in the body is essentially due to the downstream effects of its partial opioid receptor blockade. This blockade substantially elevates the bodies own endogenous endorphin and enkephalin levels. The resultant increased effect of these two powerful mediators helps to positively modulate the immune system, increasing anti-inflammatory mediators in the body, and favorably influencing the endocrine system balance of thyroid, adrenal, sex hormones.

Why Patients Need a Compounding Pharmacy—

The pharmacists at The Apothecary collaborate with medical practitioners that have the ability to personalize your LDN dose. The therapeutic window for a person’s most effective dose of LDN is narrow. A one-size-fits-all medication approach will not typically provide a high rate of successful therapeutic outcomes. To achieve the most favorable results, it is critically important for providers to customize the LDN dose for each individual patient and their condition.

No two patients are alike, and our pharmacists understand this—

Over time, as our understanding of LDN continues to evolve, The Apothecary has made it standard protocol for patients to start low and titrate to find their best individualized dose. The patient outcomes have been increasingly promising. With the capability to compound the dose and dosage form to the patient and their condition our team at The Apothecary has witnessed amazing patient outcomes.

LDN therapy is a team effort—

We have found partnership with patients and practitioners utilizing LDN as a modality of treatment has brought many patients great success. Discovering the optimal dosage of LDN can lead to life-changing health benefits. Leading LDN experts believe with LDN’s far-reaching positive effects on the immune system, there may exist a genuine reason for it to be prescribed for practically all medical conditions; this is especially true given its low cost and generally absence of unwanted effects.

Explore the clinical uses of LDN

LDN Symptom Sheet

You may check common symptoms that we track on our LDN Symptom Sheet.  If you have a considerable amount of 2’s and 3’s, this may indicate that you may benefit from taking LDN. Please talk to your provider or contact us, and we can assist you in your next steps.

Used for autoimmune conditions, inflammation, pain, mental health and overall wellness, the use of this old medication is expanding with incredible results.

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Let us answer any questions you have about LDN.

FAQ About Low Dose Naltrexone

See our color brochure about Potential Clinical Uses and Trials of LDN.

  • LDN has very unique and far reaching clinical actions; unlike the vast majority of todays medications that are prescribed to manage symptoms. As mentioned prior, LDN has positive autoimmune, pain, anti-inflammatory, dermatologic, gastro-intestinal, and mental health effects.
  • The beneficial broad range of effects that LDN creates in the body is essentially due to the downstream effects of its partial opioid receptor blockade. This blockade substantially elevates the bodies own endogenous endorphin and enkephalin levels.
  • It is both of these neurotransmitters/messengers that have significant and far reaching effects on leveling pain, the immune system and managing inflammation, and enhancing some communications with the endocrine system, and brain/mental health.


  • blocks toll-like receptor 4, which are found on macrophages such as microganglia
  • therefore LDN suppresses the inflammatory compounds , tumor necrosis -alpha and IL-6, that are contained in the macrophages
  • reduces glial cell activation
    • which down regulates and reduces inflammatory cytokine release
    • promotes reduction of neuro-inflammation
  • down regulates oncogene expression
  • modulates T & B Lymphocyte production (gastrointestinal inflammation)
  • reduces a range of inflammatory cytokines ; including IL-6, Il-12, Tumor necrosis factor -alpha
  • suppresses tumor growth factor – NF-kB
  • serotonin and dopamine neurotransmitter effects

As with almost all medications, there is not a one-size-fits-all dose. The most successful dosing strategies and protocols of LDN for individual patients are those that can be tailored by working with knowledgeable practitioners and compounding pharmacists. There is new, evolving knowledge and understanding of different effects of LDN at different dosing levels.

Typically the side effects experienced with LDN are very minimal and temporary, due to the initial effects of LDN on the immune system. Some may notice a little nausea or queasiness and some may have their sleep disturbed or have vivid dreams. These effects can be lessened by starting with lower doses, and normally are short lived and subside fairly early during treatment.

Some patients may experience negative effects later on during LDN therapy with a dosage increase; when the practitioner is attempting to achieve a better outcome than the current dose. This typically is indicator that the dosage adjustment is excessive at this point in the therapy, and a lower dose should be used.

As the most successful dosing for an individual person can vary, the duration of LDN therapy necessary for positive results has many variables and can vary from literally just days to many months. Achieving the proper dosage is the most significant factor in the successful clinical outcomes for any patient for any health condition.

Once again, a knowledgeable and experienced practitioner and compounding pharmacist can work together with each individual person to find their most successful path to improving their health.

We can share our experience for a couple of clinical conditions. Follow ups with current patients have revealed what we feel are pretty remarkable results; within one month roughly 70+% of those starting at lower doses of LDN are noting positive improvements in mental health (mood, anxiety) and energy.

Some individuals begin to experience some improvements in pain and inflammation within the first month or two. Achieving a greater relief in symptoms may be an element of further dosage adjustments and/or time.

Some literature has shown that conditions of chronic pain, gastrointestinal (crohns or ulcerative colitis), and dermatology may require 4 to 6 months of therapy or more, up to even a year, for more significant effects. Some noticeable positive changes in condition could gradually start occurring earlier in therapy.


  • Vitamin D 5,000- 10,000U Units daily
  • Probiotics, broad spectrum multi-strain
  • Omega 3 Fish Oil

Additional (depending on condition):

  • CBD Oil
  • Curcurmin
  • Magnesium
  • Zinc
  • Vitamin C

Many prescribing practitioners and LDN researchers firmly believe that broad range of beneficial actions of LDN on the immune system and inflammation would warrant using LDN as a preventative measure. Particularly as most of the disease states that afflict our population today have an underlying inflammatory component. The thought process being “why wait” until the inflammatory process progresses to a problematic state and only then begin fighting the uphill battle in attempt to reverse it.

Currently there are over 1200 PubMed studies/research articles emphasizing the use of LDN in over 150 clinical conditions, with new research being published monthly.   A couple of good websites containing links to much of this data include www.ldnresearchtrust.org  and www.ldnscience.org

Even with the successes that many of these studies have proven, their successful outcomes are limited in scope as the scientific protocols for medication studies require a single dose for all participants in the study to compare to the placebo control group.  This limits the potential positive outcomes for many of the participants in the study as the dosage strength utilized may not be their effective dose.